Traditional Chinese medicine - chemistry and application
Posted on 24. April, 2013.
Amongst the many aspects of modern Chinese chemistry described in the Journal of Chemical Research during 2012, are phytochemical investigations into the constituents of traditional Chinese medicines derived from plants and fungi. Such studies have afforded new medicines to treat diseases such as Alzheimer’s, malaria and cancer.
Advances in aromatic chemistry reported in the Journal of Chemical Research in 2012
Posted on 28. March, 2013.
During 2012 a number of useful papers have appeared in the Journal of Chemical Research reporting advances in aromatic chemistry.
First total synthesis of fuscain
Posted on 20. December, 2012.
Fuscain is a new furanolactam isolated from the sponge Phacellis fusca from the South China Sea. Furan analogues isolated from marine organisms have valuable medicinal properties. The first total synthesis of fuscain is reported in Journal of Chemical Research December issue. The key step in the synthesis is the formation of seven-membered lactam by acylation of a furan ring using the mild Lewis acid CuSO4•5H2O.
Efficient Odorant Synthesis
Posted on 20. September, 2012.
2-Nonen-4-olide occurs naturally in the volatile components of various foods and plant extracts, such as stewed beef/vegetable gravy, sunflower oil, Chinese white salted noodles watermelon, potato crisps, lard cured with spices and aromatic herbs, mushrooms, French fries, and flue-cured tobacco. It has an oily, coconut-like, and rancid odour. A simple, efficient and low cost synthesis of this odorant is reported in the August issue of Journal of Chemical Research.
Highlights in natural products published in the Journal of Chemical Research in 2011
Posted on 29. May, 2012.
Various aspects of the isolation, synthesis, chemistry and biological activity of a range of natural products were published in 2011 Journal of Chemical Research. In medicinal chemistry, most of today's antibacterials are chemically semisynthetic modifications of natural compounds emanating from trees, shrubs and fungi.
Highlights of synthetic methods published in the Journal of Chemical Research in 2011
Posted on 29. May, 2012.
During 2011 the Journal of Chemical Research published over 200 papers. Many reported the synthesis and chemistry of specific groups of compounds whilst others have described useful additions to synthetic methodology. Heck and Knoevenagel reactions, nanoparticle as catalysts are just some of the methodologies reviewed.
Micro reactors: industrial results
Posted on 24. April, 2012.
Micro reactors and flow reactors have many advantages as tools in organic synthesis. A review in the April issue of Journal of Chemical Research describes how small reactor volumes enable reactions to be performed on an industrial scale more efficiently and safely than when using batch processes.
The mechanism of the reaction of the Tollens reagent
Posted on 21. December, 2011.
The Tollens test for aldehydes has been used for over 100 years but no reason has been given for adding sodium hydroxide to the silver nitrate before the solution is cleared with ammonia. In this paper, a mechanism is proposed which explains why the addition of alkali makes the test much more sensitive.
A new labdane diterpene from Rauvolfia tetraphylla Linn. (Apocynaceae)
Posted on 24. November, 2011.
Rauvolfia tetraphylla Linn. (syn. R. canescens L., family: Apocynaceae) holds an important position in the Indian traditional system of medicine, and has other immense applications. This particular plant is regarded as a rich source of a wide variety of important alkaloid constituents such as reserpine, reserpiline, raujemidine, isoreserpiline, deserpidine, aricine, ajmaline, ajmalicine, yohimbines, serpentine, sarpagine, vellosimine and tetrphylline. However, there is no report on the terpenoid constituent from this plant, and we report the isolation from the air-dried stems and branches of R. tetraphylla and structural elucidation of a new labdane diterpene, 3-hydroxy-labda-8(17),13(14)-dien-12(15)-olide (1; Fig. 1) bearing an unusual -lactone moiety.