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The ozonolysis of terpenoids, a Pandora’s box of by-products

Posted on 30. November, 2017.

The ozonolysis of alkenes is a general reaction that has made a significant contribution to the degradation and elucidation of the structures of natural products. The cleavage of alkenes by ozone has not only provided information on their immediate structural environment but also opened up the structures of compounds for further degradation. 


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A three-coordinate Ag(I) complex based on the V-shaped ligand 1,3-bis(1- ethylbenzimidazol-2-yl)-2-thiapropane: synthesis, crystal structure and DNAbinding properties

Posted on 14. September, 2016.

The properties of benzimidazole and its derivatives have been studied under a broad spectrum of biological activities for many years. The benzimidazole moiety is found in various biologically active compounds having antiviral, antiulcer, antihypertensive, anticancer, and antihistaminic properties.


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Synthesis of 5-acetyl-2-arylamino-4-methylthiazole thiosemicarbazones under microwave irradiation and their in vitro anticancer activity

Posted on 12. February, 2016.

The thiosemicarbazone (TSC) is considered as one of the most important scaffolds and is embedded in many biologically active compounds. Brockman et al. first showed that 2-formylpyridine TSC possesses antileukemic activity in mice. Since then, various aliphatic, aromatic and heteroaromatic carbaldehyde TSCs were synthesised and many of them exhibited a broad range of biological activities.


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Chiral cyclic synthetic intermediates from readily available monoterpenoids

Posted on 4. January, 2016.

The availability of some simple chiral monoterpenoids has led to their use in various ways in synthesis. A previous article reviewed the acyclic synthons that were easily accessible from citronellol 1, linalool 2 and limonene 3. This free review article is concerned with the cyclic chiral synthons that can be readily obtained from these monoterpenoids as well as car-3-ene 4, α-pinene 5 and camphor 7. The article will group these chiral synthons in terms of the size of the ring containing the chiral fragment.


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Sonochemical synthesis and characterisation of lead sulfide nanoparticles using different capping agents

Posted on 23. November, 2015.

In recent years, it has been realised that semiconductor materials reduced to nano size have superior electrical, optical and chemical properties with respect to its macrosized counterpart. Therefore, nano-size semiconductors have attracted considerable attention.


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Total synthesis of Cannabisin B

Posted on 22. October, 2015.

Cannabisin B was first isolated from Cannabis sativa in 1992 and belongs to the group of the lignanamides which are a class of naturally occurring products that arise biosynthetically from phenylpropanoids and tyramine.


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An efficient TiCl4-catalysed method for the synthesis of para-substituted aromatic aldehydes

Posted on 13. October, 2015.

A para-substituted aromatic aldehyde is an important substructure in both natural products and therapeutic agents. 


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Practical synthesis of naringenin

Posted on 26. August, 2015.

Flavanones, 2-phenylchroman-4-ones, belong to the family of flavonoids, many of which are produced as secondary metabolites in the plant kingdom and exhibit a broad spectrum of interesting biological activities. Naringenin (5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) is one of the most abundant flavanones present in grapefruits and citrus fruits. It is well-known for its beneficial health-related properties, including anti-oxidant, anti-cancer, anti-atherogenic, antiinflammatory and anti-proliferative activities.


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A new flavonoid glycoside and potential antifungal activity of isolated constituents from the flowers of Lilium lancifolium

Posted on 12. June, 2015.

Lilium lancifolium is a medicinal plant which is widely distributed in China. In traditional Chinese medicine, its bulbs and flowers have been regularly used as sedatives, antimicrobial and anti-inflammatory agents. Some phenolic compounds and steroidal saponins have been reported from the bulbs of Lilium lancifolium.


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