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Mesenchymal Stem Cells As A Platform For Gene Therapy Protocols

Posted on 17. May, 2010.

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Viral or plasmid vectors can be used  to transform therapeutic mesenchymal stem cells for use in different pathologies.

Mesenchymal stem cells (MSCs) are considered as the adult stem cells with the greatest therapeutic potential, due to characteristics such as plasticity, intrinsic tropism towards lesions, paracrine activity, and immunosuppressive activity. This potential may be optimised by transforming them with genes which will improve their therapeutic ability or are therapeutic by themselves.

This review presents a summary of the main types of viral or plasmid vectors used to transform therapeutic MSCs and their use in different pathologies. Although this strategy holds great promise, results are still heterogeneous, showing that more studies are needed to optimise gene transfer methods and models.

TIAGO PIRES DALBERTO, NANCE BEYER NARDI AND MELISSA CAMASSOLA
Universidade Federal do Rio Grande do Sul (Brazil)

This article features in the next issue of Science Progress.

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