Search

Latest News

For all the latest news and features, sign up to receive our FREE updates by email:




Your Privacy

Organ Transplantation Has Come Of Age

Posted on 18. May, 2010.

Bookmark and Share

With more powerful and selective agents, one of the main problems in organ transplantation is a result of its success, namely a shortage of organ donors.

Organ transplantation started in the mid-1950s with a kidney transplant between identical twins, demonstrating how the surgical technique could provide successful therapy. The immunological barrier to be overcome, however, proved to be far more difficult to deal with. The introduction of immunosuppressive agents produced some success but it was not until Cyclosporin became available in the 1980s that results became sufficiently good for widespread acceptance and rapid development of organ grafting. Now with more powerful and selective agents, although there is still much room for improvement in immunosuppression, one of the main problems in organ transplantation is a result of its success, namely a shortage of organ donors.

In this review, I summarise these matters.

ROY Y. CALNE
University of Cambridge, UK

This article features in the next issue of Science Progress.

Find out more about Science Progress

Subscribe to Science Progress