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Cleavage of carbofuran and carbofuranderivatives in micellar aggregates

Posted on 22. April, 2015.

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Historically, based on carbamic acid, a large family of carbamate pesticides have been developed, and are also widely employed as insecticides. In 1988, Goto et al. reported the first synthesis of carbofuran, and also described the biological activity of various amino sulfenyl derivatives of methylcarbamate. Later, the synthesis of several procarbofurans was reported by Gaset et al. These derivatives present a substitution in the nitrogen proton by different organic groups.

The main action mechanism of carbamate pesticides that controls the insect pests is based on fast but reversible inhibition of acetyl-cholinesterase. Therefore these endocrine disrupters could have potential adverse effects on the environment and human health. 

In recent years, the stability of carbamate pesticides have been studied by this research group in a wide range of biomimetic microheterogeneous media such as micelles or reverse micelles. These microheterogeneous media included different surfactant species and, hence, different self-assembled structures. In particular, basic hydrolysis of carbofuran and its derivatives have been analysed in the presence of anionic, cationic, non-ionic and reverse micelles. The results obtained from these physicochemical and kinetic studies, as well as a consistent comparison of them, are summarised in this paper.

Read the full article in Progress in Reaction Kinetics and Mechanism Volume 40, Number 2, 2015, pp.105-118.

Authors: J. Moralesa, O.A. Moldesa, A. Cidb, G. Astraya,c and J.C. Mejutoa*

aPhysical Chemistry Department, Faculty of Sciences, University of Vigo, 32004, Ourense, Spain
bChemistry Department, REQUIMTE-CQFB, Faculty of Sciences and Technology, University Nova of Lisbon, 2829-516, Monte de Caparica, Portugal
cDepartment of Geological Sciences, College of Arts and Sciences, Ohio University, 45701 Athens, USA

Keywords: carbofuran, carbofuran-derivatives, micelles, microemulsions, pseudophase, self-assembly colloids

DOI:10.3184/146867815X14259195615547

Image: Carbofuran and carbofuran-derivatives.