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Kinetics of diffusion-controlled adsorption of adenine and adenosine in a carboxymethyl diaminoethane PVC-mediated column system

Posted on 13. March, 2015.

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The interactions of biochemical compounds, such as adenine and adenosine, with chelating resins in fixed-beds have been extensively studied. However, a literature search indicates that there are very few studies concerning the kinetics of ligand adsorption in the continuous mode.

As is well-known, the equilibrium and kinetics are the two main aspects of the adsorption process. In order to ensure the optimisation of a particular adsorption process, it is necessary to investigate the relevant factors. In a column system, the non-retained solute is continuously removed from the solid phase; hence further release of solute is not hindered by solute which has been released earlier, as is observed in batch processes; and the retention of ligands in the adsorption column depends only on their distribution between the stationary and mobile phases. For this reason, the amount of adsorbed solute is a function of both time and the affinity of the binding sites present in the stationary phase. In our previous study, the adsorption behaviours of adenine and adenosine on a cobalt-CMEDA-PVC resin were investigated by applying the Langmuir and Freundlich isotherms to the experimental data, and the results of the applied adsorption isotherms were also analysed by the Scatchard plot analysis. However, it seems that further study is needed in order to better understand the ligand adsorption processes, and regarding this point, it is also necessary to investigate the kinetics of ligand adsorption, comprehensively. With this background, the present work aimed at investigating the adsorption kinetics of adenine and adenosine on cobalt-CMEDA-PVC.

Read the full article in  Progress in Reaction Kinetics and Mechanism, Volume 40, Number 1, 2015, pp. 48-58.

Author: Ahmet Ayar
Department of Chemistry, Faculty of Sciences and Arts, University of Niğde, Niğde, Turkey
 
Keywords: adenine, adenosine, rate-controlling step, breakthrough curve, ligand-exchange, equivalent points method


DOI:10.3184/146867815X14199388748264

Image: Adenosine by Jynto - Licensed under CC0 via Wikimedia Commons / Adenine by Vesprcom - Licensed under Public Domain via Wikimedia Commons