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Posted on 14. September, 2016.
The properties of benzimidazole and its derivatives have been studied under a broad spectrum of biological activities for many years. The benzimidazole moiety is found in various biologically active compounds having antiviral, antiulcer, antihypertensive, anticancer, and antihistaminic properties.
Posted on 12. February, 2016.
The thiosemicarbazone (TSC) is considered as one of the most important scaffolds and is embedded in many biologically active compounds. Brockman et al. first showed that 2-formylpyridine TSC possesses antileukemic activity in mice. Since then, various aliphatic, aromatic and heteroaromatic carbaldehyde TSCs were synthesised and many of them exhibited a broad range of biological activities.
Posted on 4. January, 2016.
The availability of some simple chiral monoterpenoids has led to their use in various ways in synthesis. A previous article reviewed the acyclic synthons that were easily accessible from citronellol 1, linalool 2 and limonene 3. This free review article is concerned with the cyclic chiral synthons that can be readily obtained from these monoterpenoids as well as car-3-ene 4, α-pinene 5 and camphor 7. The article will group these chiral synthons in terms of the size of the ring containing the chiral fragment.
Posted on 23. November, 2015.
In recent years, it has been realised that semiconductor materials reduced to nano size have superior electrical, optical and chemical properties with respect to its macrosized counterpart. Therefore, nano-size semiconductors have attracted considerable attention.
Posted on 22. October, 2015.
Cannabisin B was first isolated from Cannabis sativa in 1992 and belongs to the group of the lignanamides which are a class of naturally occurring products that arise biosynthetically from phenylpropanoids and tyramine.
Posted on 13. October, 2015.
A para-substituted aromatic aldehyde is an important substructure in both natural products and therapeutic agents.
Posted on 26. August, 2015.
Flavanones, 2-phenylchroman-4-ones, belong to the family of flavonoids, many of which are produced as secondary metabolites in the plant kingdom and exhibit a broad spectrum of interesting biological activities. Naringenin (5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) is one of the most abundant flavanones present in grapefruits and citrus fruits. It is well-known for its beneficial health-related properties, including anti-oxidant, anti-cancer, anti-atherogenic, antiinflammatory and anti-proliferative activities.
Posted on 12. June, 2015.
Lilium lancifolium is a medicinal plant which is widely distributed in China. In traditional Chinese medicine, its bulbs and flowers have been regularly used as sedatives, antimicrobial and anti-inflammatory agents. Some phenolic compounds and steroidal saponins have been reported from the bulbs of Lilium lancifolium.
Posted on 28. April, 2015.
Squaramides have been used as linkers for bioconjugation, as pharmacophores in medicinal chemistry possessing various biological activities such as kinase inhibition, CXCR2 or vitronectin receptor modulation, and potassium channel blockade.
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