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Syntheses and structures of a class of bridged bis(amidinate)s and derivatives

Posted on 20. June, 2018.

Amidinates are versatile ligands used in the fields of coordination and organometallic chemistry because their steric and electronic properties can be easily modulated by varying the substituents on the C and N atoms.

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Advances in Steroid Chemistry

Posted on 30. March, 2015.

There are many facets to modern steroid chemistry. The isolation of novel steroids, particularly as their glycosides from medicinal plants, continues to be reported. Steroids have a wide range of valuable biological activities. The exploration of routes for the partial synthesis of the less common biologically active compounds from more readily available steroid starting materials provides important objectives.

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Free from the archives - One-pot synthesis of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyran-3-carbonitriles in aqueous media

Posted on 5. March, 2015.

The selective manipulation of one functional group in the presence of other(s) using nontoxic chemicals in economically viable and environmentally benign conditions is a formidable task for synthetic organic chemists. There is a growing interest in carrying out synthetic transformations in aqueous media.

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An improved synthesis of apigenin

Posted on 4. March, 2015.

Flavonoids are a group of common phenolic plant pigments composed of a C6–C3–C6 backbone which occur widely in higher plants and exhibit a broad spectrum of interesting biological activities including anticancer, antioxidant, neuroprotective and antihypertensive activities. Apigenin (4′,5,7-trihydroxyflavone) is a flavone which is abundantly present in common fruits, vegetables and plant-derived beverages (e.g. tea and wine), which has anti-inflammatory, free radical scavenging and anticancer effects.

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A highly selective fluorescent indicator for copper based on a boron complex

Posted on 26. February, 2015.

Fluorescent organic dyes have been widely used in metal ion detection as fluorescent probes of high sensitivity and selectivity that allow reduced sample volume. Various ions can be successfully detected with a corresponding fluorescent compound, examples being: diketopyrrolopyrrole derivatives as fluorescent probes for Zn2+, 4‑aminoantipyrine for Al3+, and 4-(8-quinolyl)amino-7-nitro-2,1,3-benzoxadiazole for Hg2+.

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Eco-friendly mono-1,4-hydrocyanation of diarenyl ketones using potassium hexacyanoferrate(II) as a cyanide source

Posted on 24. February, 2015.

The conjugate hydrocyanation of α,β-unsaturated ketones is an important C–C bond forming reaction in synthetic organic chemistry, which can produce significant β‑cyano ketones.

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Efficient, one-pot synthesis of polyfunctionalised octahydroquinazolin-2,5-diones catalysed by Fe3O4 nanoparticles

Posted on 12. February, 2015.

In recent years, multi-component reactions (MCRs) have been developed as economic methods for the synthesis of important medical and industrial compounds. MCRs are convergent reactions, in which three or more starting materials react to form a product, where basically all or most of the atoms are retained. They have become important procedures for the synthesis of structurally complex compounds in addition to drug-like molecules.

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Designing new scaffolds consisting of hepta-annulated heterocycles

Posted on 14. January, 2015.

Dendrimers are key components in the quest to build smart nanodevices for applications in a diverse range of areas including biology and medicine. The synthesis of such macromolecules has attracted the imagination of scientists, and it has already generated a large library with varied backbones.

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A novel method for the synthesis of haloisoquinolines involving an electrophile-exchange process

Posted on 24. November, 2014.

Isoquinolines are present in a wide variety of biologically active compounds and pharmaceutical agents. Haloisoquinolins have recently attracted considerable attention from both industry and academia due to their therapeutic value in a variety of diseases, showing anti-HIV-1, anticancer, antimicrobial, and antifungalproperties.

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