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Syntheses and structures of a class of bridged bis(amidinate)s and derivatives

Posted on 20. June, 2018.

Amidinates are versatile ligands used in the fields of coordination and organometallic chemistry because their steric and electronic properties can be easily modulated by varying the substituents on the C and N atoms.


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Simple conversion of thiols to disulfides in EtOH under ambient conditions without using any catalyst or additive

Posted on 10. March, 2014.

The chemistry of disulfides is a topic of high interest owing to their usefulness in chemical industry as well as for laboratory synthesis. The most notable application of disulfides is acting as operationally friendly thiolating reagents as well as precursors for sulfones/sulfoxides synthesis. 


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Synthesis, crystal structure and Cu2+ recognition of novel azobenzene derivatives

Posted on 25. February, 2014.

Copper is the third most abundant transition metal following zinc and iron in human bodies and plays a crucial role in many fundamental physiological processes in organisms. However, exposure to a high level of copper even for a short period of time can cause gastrointestinal disturbance, while long-term exposure can cause liver or kidney damage.


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Practical synthesis of neoponkoranol and its related sulfonium salt, an optimised protocol using isopropylidene as an effective protecting group

Posted on 13. January, 2014.

The inhibition of glucosidases is one of the most effective therapeutic approaches to treat diseases such as diabetes, cancers, viral infections and Gaucher’s disease. A practical synthesis of neoponkoranol and its related sulfonium salt as potent α‑glucosidase inhibitors has been developed in which the coupling reaction was optimised by using isopropylidene as an effective protecting group. The coupling yields were dramatically improved in this study from 37% to 87%.


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Antimalarial and antileishmanial activity of novel 13-benzyl-15,16-bisnorlabdane derivatives

Posted on 20. December, 2013.

Malaria and leishmaniasis are protozoan diseases with a high mortality rate affecting millions of people every year. Globally, an estimated 3.3 billion people were at risk of malaria in 2011, and estimates by the World Health Organization (WHO) have indicated that approximately 80% of cases and 90% of deaths occur in Africa, with children less than five years of age and pregnant women most severely affected. The Plasmodium falciparum parasite is responsible for most fatal cases of malaria. Leishmaniasis threatens about 350 million people in 98 countries or territories around the world, about 2 million estimated new cases occurring each year, and 12 million people are believed to be currently infected. The synthesis of 12 novel related-labdane-related natural products with antiparasitic activity is reported.


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The formation of squaramic acids and squaryl diamides by the reaction of squaric acid with alkyl isocyanides

Posted on 4. July, 2013.

The reaction between squaric acid with one equivalent of alkyl isocyanides such as t-butyl isocyanide, cyclohexyl isocyanide and n-butyl isocyanide in ethanol at room temperature after 3h afforded the corresponding squaramic acid derivatives.


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Novel uses of nanoparticle catalytic systems

Posted on 23. May, 2013.

Easily prepared and recoverable nanoparticles with a diameter of 10–40 nm, with a high surface area and stability may provide a catalytic system or the support for a catalyst.


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Traditional Chinese medicine - chemistry and application

Posted on 24. April, 2013.

Amongst the many aspects of modern Chinese chemistry described in the Journal of Chemical Research during 2012, are phytochemical investigations into the constituents of traditional Chinese medicines derived from plants and fungi. Such studies have afforded new medicines to treat diseases such as Alzheimer’s, malaria and cancer.


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Advances in aromatic chemistry reported in the Journal of Chemical Research in 2012

Posted on 28. March, 2013.

During 2012 a number of useful papers have appeared in the Journal of Chemical Research reporting advances in aromatic chemistry.


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