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Syntheses and structures of a class of bridged bis(amidinate)s and derivatives

Posted on 20. June, 2018.

Amidinates are versatile ligands used in the fields of coordination and organometallic chemistry because their steric and electronic properties can be easily modulated by varying the substituents on the C and N atoms.


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Efficient Odorant Synthesis

Posted on 20. September, 2012.

2-Nonen-4-olide occurs naturally in the volatile components of various foods and plant extracts, such as stewed beef/vegetable gravy,  sunflower oil,  Chinese white salted noodles watermelon, potato crisps,  lard cured with spices and aromatic herbs,  mushrooms, French fries, and flue-cured tobacco. It has an oily, coconut-like, and rancid odour. A simple, efficient and low cost synthesis of this odorant is reported in the August issue of Journal of Chemical Research.


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Highlights in natural products published in the Journal of Chemical Research in 2011

Posted on 29. May, 2012.

Various aspects of the isolation, synthesis, chemistry and biological activity of a range of natural products were published in 2011 Journal of Chemical Research. In medicinal chemistry, most of today's antibacterials are chemically semisynthetic modifications of natural compounds emanating from trees, shrubs and fungi.


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Highlights of synthetic methods published in the Journal of Chemical Research in 2011

Posted on 29. May, 2012.

During 2011 the Journal of Chemical Research published over 200 papers.  Many reported the synthesis and chemistry of specific groups of compounds whilst others have described useful additions to synthetic methodology.  Heck and Knoevenagel reactions, nanoparticle as catalysts are just  some of the methodologies reviewed.


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Micro reactors: industrial results

Posted on 24. April, 2012.

Micro reactors and flow reactors have many advantages as tools in organic synthesis. A review in the April issue of Journal of Chemical Research describes how small reactor volumes enable reactions to be performed on an industrial scale more efficiently and safely than when using batch processes.


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The mechanism of the reaction of the Tollens reagent

Posted on 21. December, 2011.

The Tollens test for aldehydes has been used for over 100 years but no reason has been given for adding sodium hydroxide to the silver nitrate before the solution is cleared with ammonia. In this paper, a mechanism is proposed which explains why the addition of alkali makes the test much more sensitive.


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A new labdane diterpene from Rauvolfia tetraphylla Linn. (Apocynaceae)

Posted on 24. November, 2011.

Rauvolfia tetraphylla Linn. (syn. R. canescens L., family: Apocynaceae) holds an important position in the Indian traditional system of medicine, and has other immense applications. This particular plant is regarded as a rich source of a wide variety of important alkaloid constituents such as reserpine, reserpiline, raujemidine, isoreserpiline, deserpidine, aricine, ajmaline, ajmalicine, yohimbines, serpentine, sarpagine, vellosimine and tetrphylline. However, there is no report on the terpenoid constituent from this plant, and we report the isolation from the air-dried stems and branches of R. tetraphylla and structural elucidation of a new labdane diterpene, 3-hydroxy-labda-8(17),13(14)-dien-12(15)-olide (1; Fig. 1) bearing  an unusual -lactone moiety.


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Isolation and identification of antibiotic albaflavenone from Dictyophora indusiata

Posted on 3. November, 2011.

Dictyophora indusiata is a stinkhorn fungus growing in bamboo thickets which has been used as ingredient in Chinese traditional foods for a very long time due to it delicious taste and high nutritional value. It has become a popular ingredient in Chinese cuisine because advances in its cultivation since 1979 have made it cheap and easily available. It has been observed that the broth could stay unspoiled for several days if D. indusiata were added. It has been widely recognised in Chinese folk medicine that D. indusiata has beneficial effects on some diseases, such as cough, inflammation, diarrhoea and bacterial enteritis. The chemical components and antibacterial activity of extracts of D. indusiata have been reported previously, but the components which have antibacterial activity are still unknown.


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Chemistry of B-norsteroidal 6-ketones and their relatives

Posted on 28. October, 2011.

The preparation and reactions of B-norsteroidal 6-ketones and their relatives are reviewed in the context of the stability of the A/B and B/C ring junctions and the stereochemistry of the addition reactions to the carbonyl group. This review is a sequel to a previous article on the reactions of B-norsteroidal 4- and 5-enes (C. Uyanik and J.R. Hanson, J. Chem. Res, 2009, 713.)
doi: 10.3184/174751911X13146264913491


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