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A new alkaloid from the mycelium of Inonotus obliquus

Posted on 11. April, 2014.

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Inonotus obliquus, a white rot fungus that belongs to the family Hymenochaetaceae (Basidiomycetes), is mainly distributed in Europe, Asia, and North America. It has been used for the treatment of gastrointestinal cancer, cardiovascular disease and diabetes since the 16th century in Russia, Poland and the Baltic countries and has been reported to have anti-inflammatory, antioxidant, immunomodulatory and hepatoprotective effects.

This paper reports that a new alkaloid, inotopyrrole (N-phenethyl-2-formyl-5-hydroxymethylpyrrole), was isolated from the mycelium of Inonotus obliquus, together with three known compounds. The structure of inotopyrrole was established by detailed analysis of its spectroscopic data, especially the one‑ and two‑dimensional NMR spectra and HR-ESI-MS data.

Read the full article in the Journal of Chemical Research, Vol. 38, No. 4, April 2014, pp.245-246

DOI: 10.3184/174751914X13944574433383

Image: Inonotus obliquus. Karmėlava forest, Lithuania. Courtesy of Tomas Čekanavičius, licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.