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A new steroidal glycoside and potential anticancer cytotoxic activity of compounds isolated from the bulbs of Lilium callosum

Posted on 10. November, 2014.

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Callosum A, a new steroidal glycoside, has been isolated from the n‑butanol soluble fraction of Lilium callosum, along with five known steroidal glycosides, reported for the first time from Lilium callosum.

“Bǎi-hé”, a Chinese crude drug, is prepared from the bulbs of the Lilium species and is regularly used nowadays in China as a sedative, antitussive and anti-inflammatory agent. Previously, phenolic glycosides, steroidal saponins and steroidal alkaloids have been isolated from the bulbs of the Lilium species.
However, a survey of the literature showed that to date no chemical work has been done on Lilium callosum. In order to 
investigate the constituents and screen the bioactive constituents from its bulbs, a phytochemical study was performed that resulted in the isolation of a new steroidal glycoside named as callosum A (1), along with five known steroidal saponins (2–6).
The latter were identified with funkioside D (2), Atropuroside A (3), Atropuroside C (4), (25R)-3β,17α-diol-5α-spirostan-6-one 3‑O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (5), aspidistrin (6). In this article, the authors describe the structural elucidation of new compound, together with the anticancer cytotoxic activity test performed for all isolated compounds (See above figure). 

Read the full article here, in  Journal of Chemical Research, Volume 38, Number 10, October 2014, pp. 577-579.

Authors: Xiao Wang and Guo Qing Wu

Medical Oncology, Zhejiang Provincial People’s Hospital, 158 Shangtang Road, Hangzhou, 310014, P.R. China

Keywords: Lilium callosum, callosum A, steroidal glycoside


Image: Chemical structures of compounds 1–6 isolated from the bulbs of Lilium callosum.