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A New Triterpenoid from Traditional Chinese Medicine Poria Cocos

Posted on 22. October, 2010.

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A new triterpenoid, 3,4-secolanosta-4(28),7,9,24Z-teraen-3,26-dioic acid, along with two known compounds 16-deoxyporicoic acid B and 3-epidehydrotrametenolic acid were isolated from the dried sclerotia of Poria cocos Wolf (Polyporaceae). The structures are elucidated by spectroscopic methods and literatures.

The sclerotia of Poria cocos Wolf (Polyporaceae), called Fuling in Chinese is traditionally used in Chinese prescriptions as diuretics and sedatives. Previous phytochemical investigations on the sclerotia of this species were reported to contain lanostane-type triterpene acids, some of which have been revealed to possess strong anti-inflammatory effects, cytotoxicities against human cancer cell lines, and induced apoptosis in prostate cancer cells and in H-ras-transformed rat2 cells. In addition, some triterpene acids from the epidermis of the sclerotia of P. cocos have been reported to possess inhibitory effects on DNA polymerases.