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Evaluation of genotoxic and oxidative stress response to dimethoate in freshwater fish Channa punctatus (Bloch)  

Posted on 11. June, 2014.

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Dimethoate (O, O-dimethyl S-methyl carbamoylmethyl phosphorodithioate) is a broad-use systemic organophosphate insecticide. It exerts acute toxic effects to pests by irreversible inhibition of the cholinesterase enzyme from breaking down acetylcholine. 

Due to its biodegradability and short residence time in the environment, organophosphate insecticides are being increasingly used, among which dimethoate is one of the important organophosphate insecticide indiscriminately used in India. 

It reaches the aquatic ecosystem by direct application, spray 
drift, spraying, washing from the atmospheric precipitation and runoff from agricultural lands where insecticides ravage the biotic life. Fish are particularly sensitive to environmental contamination of water and therefore, pollutants may significantly damage certain physiological and biochemical processes when they enter fish organs. Bioaccumulation of insecticide and heavy metals in the tissues of aquatic organisms may be harmful for human consumption.

The objective of this study is to evaluate the clastogenic and the genotoxic effect of dimethoate manifested by oxidative stress in freshwater fish C. punctatus.

Keywords: Channa punctatus, dimethoate, DNA damage, comet assay, oxidative stress

Authors: Daoud Alia*, Phool Gend Kumarb, Sudhir Kumarb and Mukhtar Ahmeda
aDepartment of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia
bMolecular and Human Genetic Laboratory, Department of Zoology, University of Lucknow, Lucknow -226007, 

Read the full article in Chemical Speciation and Bioavailability, Volume 26, Number 2, April 2014, pp. 111-118.


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