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Efficient, one-pot synthesis of polyfunctionalised octahydroquinazolin-2,5-diones catalysed by Fe3O4 nanoparticles

Posted on 12. February, 2015.

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In recent years, multi-component reactions (MCRs) have been developed as economic methods for the synthesis of important medical and industrial compounds. MCRs are convergent reactions, in which three or more starting materials react to form a product, where basically all or most of the atoms are retained. They have become important procedures for the synthesis of structurally complex compounds in addition to drug-like molecules.

Furthermore MCRs are effective, environmentally friendly, quick, atom economic and time-saving. They provide an efficient tool for the preparation of various compounds with biological and pharmaceutical properties. Recently, the three-component reaction of an aldehyde, dimedone and urea/thiourea to form 4-aryl-octahydroquinazolin-2,5-dione derivatives has attracted considerable attention because of their potential antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. In addition, they have showed calcium antagonist activity.

Read the full article in  Journal of Chemical Research, Volume 39, Number 1, January 2015, pp. 56-61.

Authors: Vahid Reza Hedayatia and Mohammad Ali Ghasemzadeh

Keywords: 4-aryl-octahydroquinazolin-2,5-dione, 4-aryl-octahydroquinazolin-2-thione-5-one, Fe3O4 nanoparticles, multicomponent

DOI: 10.3184/174751915X14199511243271