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Microbial biotransformation of α-ionol

Posted on 26. February, 2018.

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α-Ionol is a megastigmane derivative belonging to the most important odoriferous degradation products of β-carotene in plants and it contributes to the characteristic fragrances of many flowers.In this study, the microbial biotransformations of α-ionol by fungi were examined with the aim of producing new derivatives that could be used as potential flavour and fragrance ingredients.

Abstract
 
Ionols are important flavour and fragrance compounds both in natural and synthetic aroma blends that are used in many daily products. α-Ionol has been converted for the first time to 3-oxo-α-ionone by microbial biotransformation using the plant pathogenic fungi Aspergillus niger NRRL 326 and Fusarium culmorum (freshly isolated) over 7 d at 25 °C at 6.6 and 15.3% yield, respectively. The structure of the metabolite, which was purified by column chromatography, was elucidated by FTIR, GC-MS and NMR studies.


Authors: İsmail Kırana*, Türkan Tikna Sefunça, Özge Özşena, K. Hüsnü Can Başerb,c and Fatih Demircic,d
aEskişehir Osmangazi University, Faculty of Science and Letters, Department of Chemistry, 26480 Eskişehir, Turkey
bNear East University, Faculty of Pharmacy, Department of Pharmacognosy, Nicosia, N. Cyprus, Mersin 10, Turkey
cBadebio Biotechnology Ltd, Technopark, Anadolu University, 26470 Eskişehir, Turkey
dAnadolu University, Faculty of Pharmacy, Department of Pharmacognosy, 26470 Eskişehir, Turkey

Keywords: Aspergillus niger, Fusarium culmorum, biotransformation, ionol

Image: Biotransformation of α-ionol.

Read the full article in Journal of Chemical Research, Volume 42, Number 1, January 2018, pp. 13-14.

DOI: https://doi.org/10.3184/174751918X15161933697772